Program

Confirmed speakers:

Andrei Goga University of California, San Francisco, USA
Arkaitz Carracedo Ikerbasque, the Basque Foundation for Science, Bilbao, Spain
Arne Östman Cancer Center Karolinska Stockhom, Sweden
Channing J Der University of North Carolina at Chapel Hill, USA 
Chris Madsen Lund University, Sweden
David Cheresh University of California, San Diego, USA
Eduard Batlle IRB Barcelona, Spain
Erik Sahai Francis Crick Institute, London, UK
Eyal Gottlieb Technion Integrated Cancer Centre, Haifa, Israel
Hector Herranz University of Copenhagen, Denmark
James B Lorens University of Bergen, Norway
Judith A Varner University of California, San Diego, USA
Karl-Johan Malmberg Institute for Cancer Research, Oslo, Norway
Adrienne D Cox University of North Carolina at Chapel Hill, USA
Lars A Akslen University of Bergen, Norway
Peter Friedl Radboud University Medical Centre, Netherlands
Santiago Zelenay Cancer Research UK, Manchester Institute, UK 
Teresa A Zimmers  Indiana University School of Medicine, USA
Valerie M Veaver University of California, San Francisco, USA
June 20th
08:00 – 09:00 Registration
09:00 – 09:05 Welcoming address

Kjetil Taskén, Director of the Institute for Cancer Research

09:05 – 10:00 Tissue tension and risk to malignancy

Valerie M. Weaver – University of California, San Francisco, USA

Opening Keynote EACR lecture

Session 1: Tumor Microenvironment

Chairs: Kjetil Taskén and Anna Barkovskaya

10:00 – 10:40 Mining tumor collections for stroma-derived prognostic and response-predictive biomarkers

Arne Östman – Cancer Center Karolinska Stockholm, Sweden

10:40 – 11:10 Coffee break
11:10 – 11:50 Drugging undruggable RAS for cancer treatment

Channing J Der – University of  North Carolina at Chapel Hill, USA

11:50 – 12:10 Investigating the impact of DNA Base-excision repair deficiency on tumor-stroma (selected poster presentation)

Elena Clementi – Vetsuisse Faculty, Zurich, Switzerland

12:10 – 12:50 Features of the tumor microenvironment in breast cancer

Lars Akslen – University of Bergen, Norway

12:50 – 14:00 Lunch
14:00 – 15:00 Poster session

Session 2: Initiation and Niche Formation

Chairs: Therese Sørlie and Jens Henrik Norum

15:00 – 15:40 Imaging ECM remodeling during cancer progression and metastasis

Chris Madsen – Lund University, Sweden

15:40 – 16:20 Tumor plasticity, therapy resistance and immune evasion: the role of the Axl receptor tyrosine kinase

James B. Lorens – University of Bergen, Norway

16:20 – 17:00 Coffee break
17:00 – 17:40 Immune evasion and metastasis in colorectal cancer

Eduard Batlle – IRB, Barcelona, Spain

17:40 – 18:00 WDFY2 restrains matrix metalloprotease secretion and cell invasion by retention of VAMP3 in endosomal tubules (selected poster presentation)

Marte Sneeggen – The Norwegian Radium Hospital, Oslo, Norway

18:30 Get-together in the old building of the Holmenkollen Park Hotel
June 21st

Session 3: Tumor-Stroma Interaction

Chairs: Anne-Lise Børresen-Dale and Thomas Fleischer

09:00 – 10:00 Kinetics of tumor-stroma interaction, immune effector function and resistance

Peter Friedl – Radboud University Nijmegen, The Netherlands

Keynote

10:00 – 10:40 New mechanisms of tumor-stroma crosstalk

Erik Sahai – Francis Crick Institute, London, UK

10:40 – 11:00 Coffee break
11:00 – 11:40 A fly approach to tumor-stroma interaction

Hector Herranz – University of Copenhagen, Denmark

11:40 – 12:00 AML-associated mesenchymal stromal cells support growth of leukemic cells in a Gfi dependent manner (selected poster presentation)

Yahya Al-Matary – Essen University, Germany

12:00 – 13:00 Poster session
13:00 – 14:30 Lunch

Session 4: Immunity and Inflammation in Cancer

Chairs: Karl-Johan Malmberg and Yngvild Nuvin Blaker

14:30 – 15:10 Controlling tumor-associated macrophages for cancer immune therapy

Judith A. Varner – University of California, San Diego, USA

15:10 – 15:50 Molecular memory in human natural killer cells

Karl-Johan Malmberg – The Norwegian Radium Hospital, Oslo, Norway

15:50 – 16:20 Coffee break
16:20 – 17:00 Manipulating inflammation to raise cancer immunogenecity

Santiago Zelenay – Cancer Research UK, Manchester Institute, UK

17:00 – 17:40 Fuel and oil for the cancer engine

Arkaitz Carracedo – CIC bioGUNE, Bilbao, Spain

19:00 City Hall Reception
June 22nd

Session 5: Metabolism in Cancer

Chairs: Tor Erik Rusten and Rojyar Khezri

09:00 – 10:00 From Oncometabolites to metabolic vulnerabilities

Eyal Gottlieb – Technion Integrated Cancer Center, Haifa, Israel

Keynote, Dentist Olaf Aase and wife Memorial Lecture

10:00 – 10:40 ERK inhibition increases pancreatic cancer dependency on autophagy

Adrienne D. Cox – University of North Carolina at Chapel Hill, USA

10:40 – 11:00 Discovery and development of small molecules for targeting down-regulation of PDL1 in the potential immunotherapeutic treatment of leukemia (selected poster presentation)

Richard Crispin – The Norwegian Radium Hospital, Oslo, Norway

11:00 – 11:40 Coffee break
11:40 – 12:20 Regulation of metabolism by host-tumor interactions and cancer

Andrei Goga – University of California, San Francisco, USA

12:20 – 13:00 Pre-clinical and clinical studies of tumor-host interactions in muscle and fat wasting in pancreatic cancer cachexia

Teresa A. Zimmers – Indiana University School of Medicine, USA

13:00 – 13:20 Lipidomic analysis of epithelial to mesenchymal transition in breast epithelial cell lines by UPLC-MS and stable isotope tracing (selected poster presentation)

Skarphedinn Halldorson – Center for Systems Biology, University of Iceland, Reykjavik, Iceland

13:20 – 13:30 Concluding remarks

Therese Sørlie and Tor Erik Rusten

13:30 Departure